hiv integrase การใช้

• During the integration process, the HIV integrase enzyme performs two key catalytic reactions.
• A spokesman, Rick Koenig, said, " We believe HIV integrase is a promising target.
• This reaction is the key step to for the synthesis of a HIV integrase inhibitor, Crixivan.
• Dolutegravir, an HIV integrase inhibitor, is approved for the treatment of HIV / AIDS . FDA
• The interaction between HIV integrase and human LEDGF / p75 is a promising target for anti-HIV drug discovery.
• P21 mediates the resistance of hematopoietic cells to an infection with HIV by complexing with the HIV integrase and thereby aborting chromosomal integration of the provirus.
• Datasets in SAMPL4 consisted of binding affinities for host-guest systems and HIV integrase inhibitors, as well as hydration free energies of small molecules.
• In November 2005, data from a phase 2 study of an investigational HIV integrase inhibitor, MK-0518, demonstrated that the compound has potent antiviral activity.
• Viruses can also contain enzymes for infecting cells, such as the HIV integrase and reverse transcriptase, or for viral release from cells, like the influenza virus neuraminidase.
• This molecule has been found to inhibit the action of HIV integrase, an enzyme which is responsible for the introduction of HIV viral RNA into a host's cellular DNA.
• The molecule has been found to inhibit the action of HIV integrase, an enzyme which is responsible for the introduction of HIV viral DNA into a host's cellular DNA . It is not known that globoidnan A inhibits the action of other retroviral integrases.
• In the strand transfer reaction, these processed 3-prime viral DNA ends are covalently bound to the host chromosomal DNA . Integrasone inhibits HIV integrase activity by interfering with the strand transfer reaction, with an IC 50 ( half maximal inhibitory concentration ) of 41 ?M.
• First is the 3 processing of the HIV DNA, followed by strand transfer of the HIV DNA into the host DNA . The integration of HIV DNA can occur either in dividing or resting cells, and the HIV integrase enzyme can exist in the form of a monomer, dimer, tetramer, and possibly even higher-order forms ( such as octomers ).
• These include Januvia ( the first DPP-4 inhibitor for type 2 diabetes ), Gardasil ( the first vaccine for prevention of cervical cancer ), Isentress ( the first HIV integrase inhibitor ), Zostavax ( the first vaccine for the prevention of shingles in adults ), Rotateq ( an oral vaccine for the prevention of rotavirus infection in infants ), and Victrelis ( the first hepatitis C protease inhibitor ).